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My mileage will do that when I’m climbing a mountain doing 85mph and then turn around and come back down but doing the speed limit. This doesn’t indicate a problem.
Now, if you said “not only did I go from a steady 45 mpg to all of a sudden 22mpg over the last four tanks and the bike just runs like garbage!” then we’ve got something to go off of! But if you say “My mileage varies a lot over time and distance, but the bike runs like a champ!” then I would say that’s normal.